Md Abdus Subhan
Shah Jalal University of Science and Technology,Bangladesh
Title: Biological and Micellar Properties of Nano Transition Metal (Co, Fe, Ni, Cu and Zn) Complexes of 4-(1H-Imidazo[4,5-f][1,10]Phenanthroline-2-yl)-N,Ndimethylbenzene Amine
Biography
Biography: Md Abdus Subhan
Abstract
Novel ligand, 4-(1H-Imidazo [4,5-f] [1,10] Phenanthroline-2-yl)-N,Ndimethyl benzene amine(L) (Scheme) was synthesized from 1,10-Phenantroline. Nano transition metal (Co, Fe, Ni, Cu and Zn) complexes of this ligand have been synthesized. Another metal complex of cobalt with (E)-2-styryl-1H-Imidazo[4,5-f][1,10]phenanthroline(L¢) ligand has also been synthesized and characterized. The ligand and the metal complexes were characterized by UV-Visible, FTIR, AFM and Mass spectrometry. AFM study (scheme) showed that the average roughness of the [Co(L)2(Ac)2], [Fe(L)2(Ac)2], [Ni(L)2(Ac)2], [Cu(L)2(Ac)2], [Zn(L)2(Ac)2] and [Co(L¢)2(Ac)2] are 14, 10.9, 5.9, 73, 4.42 and 101.42 respectively. The particle size of the metal complexes [Co(L)2(Ac)2], [Fe(L)2(Ac)2], [Ni(L)2(Ac)2], [Cu(L)2(Ac)2], [Zn(L)2(Ac)2] and [Co(L¢)2(Ac)2] observed are 73.7, 184.6, 145, 222.45, 62 nm and 1.33 μm, respectively,
DNA binding study of the synthesized metal complexes showed that the nano metal complexes are strong DNA binding and cleaving materials. The study of micellar behavior of SDS in presence of metal complexes in aqueous solutions was carried out by measuring the absorbance of 1-(2-pyridylazo)-2- naphthol (PAN) at 470 nm. The complexes [Co(L)2(Ac)2], [Fe(L)2(Ac)2], [Ni(L)2(Ac)2], [Cu(L)2(Ac)2], [Zn(L)2(Ac)2] and [Co(L¢)2(Ac)2] were found to decrease the CMC value of SDS. Negative values for of SDS are observed for the metal complexes. Negative values of indicated that the process of micellization is thermodynamically favorable. In this presentation we will also discuss our recent work on trimetallic nanocomposite oxide particles and their medicinal applications.