N. Benkirane jessel
INSERM, France
Title: Living Implant Fortified with active therapeutics and Well organized Stem cells spheroids for Regenerative NanoMedicine
Biography
Biography: N. Benkirane jessel
Abstract
Recently, We have reported an active nanostructured collagen implant reinforced with human stem cells for bone regeneration. In our group, we have reported a "Smart Hybrid Materials Equipped with Nanoreservoirs of Therapeutics and stem cells spheroids ". This unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine. The cell contact-dependent bioerodable nanoreservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated cell-therapy implants capable of robust and durable regeneration of a broad variety of tissues.
Clinical trial: phase 1 Horizon 2020, (FR, UK, SP, SW) submitted
Feasibility and safety assessment of a therapeutic implant based on a bioactive collagen membrane and autologous mesenchymal stem cells derived from bone marrow for the treatment of femoral cartilage isolated lesions