Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend International Conference and Exhibition on Pharmaceutical Nanotechnology and Nanomedicine Las Vegas, Nevada, USA.

Day 1 :

Keynote Forum

P R Raghavan

Nanorx Inc., USA

Keynote: Nurture though nature: The story of metadichol: A unique nano lipid

Time : 08:40-09:20

 Pharma Nano 2018 International Conference Keynote Speaker P R Raghavan photo
Biography:

P R Raghavan is a CEO of Nanorx Inc. and has a PhD in Organic Chemistry from Oregon State University (1979) and an MS in Chemistry (1972) from IIT, Mumbai, India. He has worked on drug discovery for over 25 years at Columbia University, Max-Planck Institute, Germany, Ciba-Geigy (now Novartis) and Boehringer Ingelheim. He has over 15 US and international patents and another 15 pending patent applications

Abstract:

Metadichol (US patent 8,722,093 and 9043,383) is a nano emulsion of long-chain alcohols found in many foods that is present in foods such as rice, sugar cane, wheat and peanuts. Metadichol acts as inverse/Protean agonist on Nuclear Vitamin D receptors (VDR) (US patents 9,006,292, 8,722.093, 9.034, 383) that are present in cells throughout the body to stimulate the immune system. Metadichol® is first of a class of unique nano emulsion molecules that are active against viruses, bacteria, and parasites. In addition to acting on VDR, it shows cross reactivity against other nuclear receptors and how this leads to mitigation of various chronic diseases like diabetes, hypertension etc. Gene expression analysis and human clinical case studies will be presented. Because, it consists of natural components of conventional foods and has no known negative side effects, Metadichol has the potential to serve as a novel, broad-spectrum treatment for many diseases that confront public health today bringing the concept of health care for all at a price we can afford

 Pharma Nano 2018 International Conference Keynote Speaker Thomas J Webster photo
Biography:

Thomas J Webster is the Chemical Engineering Art Zafiropoulo Chair at Northeastern University. His lab group published 9 textbooks, 48 book chapters, 403 articles, and 32 provisional/full patents. He has received numerous honors: 2012, Fellow, American Institute for Medical and Biological Engineering; 2013, Fellow, Biomedical Engineering Society; 2015, Wenzhou 580 Award; 2015, Zhejiang 1000 Talent Program; 2016, IMRC Chinese Academy of Science Lee-Hsun Lecture Award; 2016, Fellow, Biomaterials Science and Engineering; and 2016, Acta Biomaterialia Silver Award. He has regularly appeared on BBC, NBC, ABC, Fox, National Geographic, and many other news outlets. 144 students have graduated under him

Abstract:

Objective: Nanotechnology (or the use of materials with one dimension less than 100nm) has been revolutionizing the field of medicine for several decades due to the ability of nanomaterials to mimic natural features of healthy tissues. However, issues remain such as toxicity, assembling nanomaterials into functional organs, efficacy, drug loading, cost and lengthy FDA approval times have still proven to be significant obstacles. The objective of this talk is to summarize recent advances in developing nanostructured artificial organs for quick regulatory approval.
Methods: Approaches such as top-down and bottom-up nano approaches along with 3D printing, cast-molding, and other techniques to create artificial organs will be covered. Approaches have been shown to be versatile using ceramics, metals, polymers and composites thereof. In vitro and in vivo studies will be covered. Nanoparticle synthesis will also be covered with challenges and promises.
Results: Such approaches have led to improved interactions with mammalian cells (such as bone, cartilage, vascular, neural, bladder, etc.,) and decreased interactions with immune cells (such as monocytes, macrophages, etc.,) to regenerate organs. Recently, results have shown the ability to decrease bacteria functions without using antibiotics. Lastly, a new approach to medicine focused on controlling Pico scale events will also be introduced where one can dictate electron interactions within a material to improve cellular functions leading to greater organ regeneration.
Conclusions: In summary, this talk will cover what has been learned over the past several decades of translating nanotechnology to improve organ replacement while emphasizing future developments that we should expect for the field to grow (such as Picotechnology).

Keynote Forum

Chad Schwartz

Beckman Coulter Life Sciences, USA

Keynote: Advancing science through discovery (Exhibitor)

Time : 10:20-10:35

 Pharma Nano 2018 International Conference Keynote Speaker Chad Schwartz photo
Biography:

Abstract:

 Pharma Nano 2018 International Conference Keynote Speaker Oara Neumann photo
Biography:

Oara Neumann has completed her PhD and Post-doctoral study in Applied Physics at Rice University and MS from Weizmann Institute of Science, Israel, and Bucharest University, Romania. She is a Research Scientist in Naomi Halas group at Rice University. She holds 12 patents and has published more than 25 papers in reputed journals.

Abstract:

Multifunctional plasmonic nanostructures have enormous potential in the treatment of solid tumors; however, tracking particles with drug cargo and triggering the release of the cargo in mapped tumors is still impossible. To overcome this challenge, we have developed an MRI and fluorescent active nanostructure nanomatryoshka. This new nanostructure with IR plasmonic signatures is composed of a 50nm Au core surrounded by dye molecules and Gd(III)-DOTA chelate doped SiO2 inner-shell and an outer Au shell. The experimental results demonstrate an enhanced T1 relaxation (r1 ~ 24mM-1s-1 at 4.7 T) compared to the clinical Gd(III)-DOTA chelating agents (r1 ~ 4mM-1s-1). Further, this design preserves the fluorescence signal (65%) after 24 hours of exposure, leading to enhanced fluorescence photostability (23x). This dual-imaging functionality nanosystem increases MRI sensitivity by concentrating Gd(III) ions into the Gd-NMs, reduces the potential toxicity of Gd(III) ions and dye molecules by preventing their release in vivo through the outer Au shell protection, and the terminal gold layer surface can then be functionalized to increase cellular uptake, circulation time, or thermal drug-release properties.

 Pharma Nano 2018 International Conference Keynote Speaker Yashwant Pathak photo
Biography:

Yashwant Pathak has completed his PhD in Pharmaceutical Technology from Nagpur University, India and EMBA and MS in Conflict Management from Sullivan University. He is a Professor and Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida, Tampa, Florida. He has extensive experience in academia as well as industry, has more than 150 publications and two patents and two patent applications, 16 books including five books in Nanotechnology and five in Nutraceuticals and Drug Delivery Systems

Abstract:

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people 50 years of age or older in the developed world. More than eight million Americans have age-related macular degeneration, and the overall prevalence of advanced age-related macular degeneration is projected to increase by more than 50% by the year 2020. Recent advances in clinical research helps in better understanding of the genetics and pathophysiology of AMD. The systemic biology information which has revealed several mechanisms causing the AMD which can be used for developing new therapies designed to prevent and help treat it the AMD. With the advances in nanotechnology, characterization techniques of nanoparticles and the enormous surface nanoparticles provide if used as a carrier for drug, researches in the ophthalmic drug delivery are gearing towards using these NPDDS (Nano-particulate drug delivery systems) for treating AMD. We have used thermo reversible polymeric gel systems to deliver various drugs which hold promises to treat mitigate and prevent AMD. The review will cover various strategies based on systemic biology of AMD and our efforts to deliver the appropriate drugs to treat various symptoms of AMD using NPDDS.

Keynote Forum

Jordi Arbiol

Catalan Institute of Nanoscience and Nanotechnology, Spain

Keynote: Free-standing nanostructures at atomic scale: From growth mechanisms to local properties at the nanoscale

Time : 11:55-12:35

 Pharma Nano 2018 International Conference Keynote Speaker Jordi Arbiol photo
Biography:

Jordi Arbiol has completed his graduation in Physics at Universitat de Barcelona (UB) in 1997, where he also obtained his PhD (European Doctorate and PhD Extraordinary Award) in 2001. He was an Assistant Professor at UB. From 2009 to 2015, he was the Group Leader at Institut de Ciència de Materials de Barcelona,
ICMAB-CSIC. Since 2017, he has been the President of Spanish Microscopy Society (SME). Since 2015, he has become the leader of the Group of Advanced Electron Nanoscopy at Institut Català de Nanociència i Nanotecnologia (ICN2). He has been awarded with the EU40 Materials Prize 2014 (E-MRS) 2014 EMS Outstanding Paper Award and the PhD Extraordinary Award in 2001.

Abstract:

Technology at the nanoscale has become one of the main challenges in science as new physical effects appear and can be modulated at will. Superconductors, materials for spintronics, electronics, optoelectronics, sensing, energy applications and new generations of functionalized materials are taking advantage of the low dimensionality, improving their properties and opening a new range of applications. As developments in materials science are pushing to the size limits of physics and chemistry, there is a critical need for understanding the origin of these unique physical properties (optical and electronic) and relate them to the changes originated at the atomic scale, e.g., linked to changes in (electronic) structure of the material. In the present work, I will show how combining advanced electron microscopy imaging with electron spectroscopy, as well as cathodoluminescence in an aberration corrected STEM will allow us to probe the elemental composition and electronic structure simultaneously with the optical properties in unprecedented spatial detail. The talk will focus on several examples in advanced nanomaterials for optical, electronics and energy applications. In this way, the latest results obtained by my group on direct visualizing and modeling materials at atomic scale will help to understand their growth mechanisms (sometimes complex) and correlate their physical and chemical properties at sub-nanometer with their atomic scale structure. The examples will cover a wide range of nanomaterials: quantum structures self-assembled in a nanowire: quantum wires (1D) and quantum dots (0D) and other complex nanowire-like morphologies for photonic and energy applications (LEDs, lasers, quantum computing, single photon emitters, water splitting cells and batteries).

Keynote Forum

Eleonora Babayants

Galaxy Consulting, USA

Keynote: GxP/GMP and its consequences for documentation and information technology systems

Time : 13:30-14:30

 Pharma Nano 2018 International Conference Keynote Speaker Eleonora Babayants photo
Biography:

Eleonora Babayants is the Founder and President of Galaxy Consulting. She is a Documentation Management Professional and hands-on consultant with over 25 years of experience in Documentation and Records Management, Document Control, Regulatory Compliance, Internal and External Auditing, Electronic Document Management Systems, Information Governance, and Change Management. Her past work includes Development and Implementation Regulatory Compliance Processes and Procedures, Leading Implementation and Administration of Document Control Systems in full Compliance with Regulatory Requirements, Enabling
Enterprise Search, Improving Systems Information Architecture, Creating and Implementing Users Training Programs. She led Electronic Document Management Systems Selection and Deployment, administered and supported these systems, Web Information Portals, Knowledgebase Applications, Recommended and Implemented Re-Structuring of the content and the Information Architecture of these systems. She has worked very closely with IT to do feasibility assessment and to capture users’ requirements. Her experience spans multiple industries including Biomedical, Pharmaceutical, and Medical Devices Companies.

Abstract:

Documentation is a critical tool for ensuring GxP/GMP compliance. This is what GMP states about document control: Each manufacturer shall establish and maintain procedures to control all documents that are required. In the regulated environment which must be GxP/GMP compliant, document control is the cornerstone of the quality system. It is so important that if an external audit identifies deficiencies in the document control system, the entire organization can be shut down. There are also GMP requirements for information technology. For a drug to be produced in a GxP/GMP compliant manner, some
specific information technology practices must be followed. Computer systems involved in the development, manufacture, and
sale of regulated product must meet certain requirements. Change control within quality management systems (QMS) and information technology (IT) systems is a formal process used to ensure that changes to a product or system are introduced in a controlled and coordinated manner. In the regulated industries, manufactures are required to use a change control procedure. In this presentation, I will discuss the connection between GxP/GMP and document control. I will describe details of document control procedures and the role of Quality Assurance in the documentation systems. I will review GMP requirements for information technology and how computer systems including documentation management systems must meet GxP/GMP requirements. I will also review change control procedure and how it should be used in GxP/GMP environment.

Keynote Forum

Branislav Vlahovic

NASA University Research Center, USAin

Keynote: Highly selective and sensitive biochemical detector for medical applications

Time : 14:30-15:10

 Pharma Nano 2018 International Conference Keynote Speaker Branislav Vlahovic photo
Biography:

Branislav Vlahovic is the Director of the National Science Foundation Computational Center of Research Excellence, NASA University Research Center for Aerospace Device and NSF Center Partnership for Research and Education in Materials at North Carolina Central University. In 2004, he was awarded by the Board of Governors of the University of North Carolina Oliver Max Gardner statewide award for his research and contribution to science. He has published more than 300 papers in peer reviewed journals on: Nanotechnology, Nanostructures, Tunneling and Charge Transfer between Nanostructures, Pulsed Laser Deposition, Nonlinear Optics, Detectors and Devices, Nano Photonics, Semiconductor Structures, Photovoltaic, and Genomics.

Abstract:

We consider that novel biochemical sensor based on the charge transfer between detector’s semiconductor nanostructures and analyte molecules that will be detected. It is an original concept that relies on the tunneling between an analyte molecule and the discrete energy levels of the detector’s nanostructures. The energy levels in nanostructures, which depend on quantum confinement and external effects, are tailored to mimic the energy levels of the analyte to be detected. Charge tunneling between the detector’s nanostructures and the analyte will occur only if the analyte has the energy levels matching the energy levels of the detector’s nanostructures. This completely new concept for biochemical sensor, which leverages the unique properties of nanostructured materials and design and optimization of detector’s nanostructure’s, provides label free detection and identification of a wide range of analyses, with single molecule sensitivities. Such unique detection method allows for continuous, instantaneous real time, high selectivity, high sensitivity, miniature in situ characterization device that could be implemented for various medical applications. The sensor may be a standalone unit, or it can serve as a part of an instrument, enhancing selectivity and sensitivity of that device. Discussed will be modeling of the optoelectronic properties of nanoscale materials and QDs for realistic QD detector ensembles, including the study of collective effects on energy level spectra and charge transfer processes between nanostructures; its application for detection in fluids; and the production of the sensor components and the final prototype device in our nanotechnology laboratory

 Pharma Nano 2018 International Conference Keynote Speaker Alberto Coelho photo
Biography:

Alberto Coelho has completed his PhD in Pharmacy from Universidade de Santiago de Compostela (2003, Spain) and Post-doctoral studies in Europe (Belgium, Italy and Portugal). He is a Member of the Instituto de Cerámica de Galicia (Spain). He has published more than 50 papers in reputed journals and has been serving as an Editorial Board Member of repute. His expertise is focused on Medicinal Chemistry, Drug Discovery, Catalysis and Nanomaterials

Abstract:

The application of efficient catalytic processes instead of stoichiometric ones is a main requirement for a sustainable and environmentally friendly chemistry. Developing hybrid heterogeneous catalysts with multiple active sites, as well as designing sequential reactions using multiple catalysts in the same reaction vessel with eco-friendly conditions are ambitious challenges to achieve the objectives mentioned above. Shape and size are key aspects in the design of heterogeneous catalysts. However, integration of micro and macroscopic properties in the design of new devices and three-dimensional shape defined catalysts is an aspect barely explored so far. 3D printing technology offers the key advantage of the fabrication of threedimensional physical objects from a digital model, taking a virtual design from computer aid design (CAD) software and its reproduction layer by layer until the physical definition of the layers gives the designed product. In addition, 3D printing can make a significant impact in the field of the chemical synthesis and catalyst manufacturing, in particular because the easy and economy which 3D-printers currently available permits a broad spectrum of materials to be printed, including solutions of comparatively low viscosity. The application of 3D-printed devices, appropriately modified on the surface, to perform complex catalytic processes such as multicatalytic multicomponent reactions (MMCRs) is a field nothing explored at all. In this work, we address the different chemical strategies for the appropriate functionalization of ceramic materials obtained by 3D-printing, as well as the combined application of these obtained 3D-monolithic catalysts, reacting cooperatively, in the development of new designed MMCRs.

  • Bionanotechnology | Nanoscale materials | Nanocomposites | Nanoparticles and Nanomedicine | Emerging Nanomedicine | Computational Studies in Nanoparticles | Research and Development of Nanomedicine
Location: las vegas, USA
Speaker

Chair

Istvan Toth

The University of Queensland, Australia

Speaker

Co-Chair

Jordi Arbiol

Catalan Institute of Nanoscience and Nanotechnology, Spain Session

Session Introduction

Long-ping Wen

South China University of Technology, China

Title: Exploiting nanomaterial-induced pro-survival autophagy for cancer therapy

Time : 16:10-16:30

Speaker
Biography:

Long-ping Wen has graduated from Xiamen University in 1982 (BS) and obtained his PhD from University of California, Los Angeles, USA in 1988. He has over 30 years of experience in Biomedical Research at various Academic Institutions in the USA, Singapore and China. He is currently a Full Professor at South China University of Technology, with a research interest focusing on Nanobiology and Nanomedicine. He has published over 100 papers, including 51 corresponding author papers during the past 10 years, in the various Sci journals such as Nature Biotechnology and Nature Materials

Abstract:

Autophagy, a key cellular degradation process, is a common response of cells upon exposure to nanomaterials. A variety of nanomaterials, including carbon, metal, and rare earth oxide nanoparticles, have been demonstrated to induce elevated level of autophagy in different cell types. Autophagy induced by nanomaterials may be either pro-survival or pro-death, and the different fate on the affected cell can be differentially exploited to enhance cancer therapy. In this talk, I will focus on the pro-survival aspect of the autophagy induced by namomaterials and how it may be exploited for cancer therapy. First, I will summarize our published work on silver nanoparticle-induced autophagy, its pro-survival nature and the enhanced therapeutic efficacy upon its inhibition. Then I will present our recent unpublished work on cancer photothermal therapy (PTT) facilitated by a type of CuPd tetrapod nanoparticles (CuPd TNPs-1). These unique nanoparticles exhibited superior NIR-assisted photothermal conversion efficiency and induced pro-survival autophagy in a shape- and composition-dependent manner. Inhibition of autophagy with the autophagy inhibitor 3-methyl adenine (3-MA) had a remarkable synergistic effect on the anti-cancer efficacy of CuPd TNPs-1-mediated PTT both in triple-negative (4T1) and drug-resistant (MCF7/MDR) breast cancer models, as it helped to achieve a level of efficacy unattainable with CuPd TNPs-2, the similarly shaped alloy nanoparticle that had a higher photothermal conversion efficiency but no autophagy-inducing activity. This work provided a proof-ofconcept for a novel chemo-PTT strategy, in which traditional chemotherapeutic agents are replaced by autophagy inhibitors. This strategy is applicable to any PTT-ready nanomaterial with the capability of inducing pro-survival autophagy and should be particularly useful for eradicating drug-resistant cancer.

Biography:

Daniel Chojnowski is an Intellectual Property Attorney who concentrates his practice in the chemical and material science arts. His practice includes global patent procurement and opinion preparation. He also counsels clients on clearance/freedom-to-practice issues, as well as on strategies for management of their global intellectual property portfolios. Prior to becoming an attorney, he was employed as an RD&I Chemist

Abstract:

Companies are often forced to internally debate whether to apply for a patent or keep the invention “secret.” This question is particularly ripe in the field of nanotechnology, where methods of producing nano particles/structures are difficult to reservably engineer. Thus, the consequences of the public disclosure mandated during the patenting process can be especially harsh if an attempt to obtain a patent is ultimately unsuccessful. This presentation will explore the essential factors that should be balanced when debating whether to apply for a patent or maintain a trade secret. This presentation will also discuss relatively new procedures at the United States Patent and Trademark Office that, if leveraged correctly, will allow an applicant to have its cake and eat it too.

Speaker
Biography:

Shuhua Bai has obtained his PhD from the School of Pharmacy, Texas Tech University Health Sciences Center. He is an Associate Professor in the School of Pharmacy, Husson University. He has had more than 16-years of research experience on the Nanoparticle-based drug delivery and development. He has published more than 30 research papers in reputed journals. He recently received the 2017 Pharmaceutical Research Meritorious Manuscript Award, presented by the American Association of Pharmaceutical Scientists (AAPS)

Abstract:

Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells. In this study, we propose to package therapeutics agents in endogenous nanovesicles, known as exosomes, derived from cancer cells. It is expected that autologous cancer cell-derived exosomes can be taken by cancer cells themselves via homing selectivity and bring the entire payload to the autologous tumor cells. Exosomes were isolated from human adenocarcinoma A549 and brain endothelial bEND.3 cell cultures using centrifugation. They presented nanosized vesicles measured by a nanosizing system. Fluorescent rhodamine 123 and anticancer drugs including paclitaxel and doxorubicin were incorporated into exosome nanoparticles by diffusion. Designed siRNA to inhibit Intercellular Adhesion Molecule-1 (ICAM-1) was loaded into exosome with the assistance of transfection reagent. Fluorescence intensity in the cells treated with autologous cell-derived exosome delivered markers was significantly increased. Exosome-delivered anticancer drugs significantly decreased cell viability in autologous cells compared to other exosomes. Exosome-delivered siRNAs significantly enhanced the knockdown efficacy compared to siRNA alone, dependent on exosome original sources and loading methods. ICAM-1 siRNA formulated in autologous lung cell-derived exosomes with the assistance of transfection agent showed the best inhibitory effect on the ICAM-1 expression compared to other treatments. Cancer cell-derived exosomes could be used as effective carriers, bringing therapeutic agents into the cells and increasing efficacy to their parental cells. The use of cancer cell-derived exosomes will be further investigated for individualized and targeted lung cancer therapy

Biography:

Amparo Verdu Solis holds a University Degree in Industrial Chemistry by the Polytechnic University of Valencia and Master’s in Plastics and Rubber Materials. For 10 years, she developed her career as Researcher in AIMPLAS, Plastics Technology Centre. Currently, she is the R&D Project Manager of Bioinicia, SL, experts
in Nanotechnology and Electro-Hydro Dynamic Processing. She has collaborated as an Expert Member in the European Committee for Standardization CEN/TC 249/WG 7/TG one Biodegradable mulch films. Now, she is involved in SBIOC Spanish BioCluster as President of the Cluster.

Abstract:

Nanocomposites have special physical and chemical properties and an array of potential applications, in particular they can be used to adapt surface properties and introduce additional functionalities. Performance of nanocomposites depends on a number of parameters, but nanoparticles dispersion and distribution state remain the key challenge in order to obtain the full nanocomposites’ potential. Optinanopro project has worked to demonstrate the benefits of the introduction of nanotechnology into packaging, automotive and photovoltaic materials production lines. Special mention to the development
and industrial integration of electrospray nano-deposition, online dispersion and monitoring system to ensure a constant quality of produced nanocomposites. Nano-enhanced coating has been applied by electrospinning, a phenomenon that occurs
when an appropriate electric field is applied to a conductive solution. Electrospinning technology has been used to obtain both self-cleaning OPVs and product repellent surfaces (with tailored repellence to selected liquids) for easy emptying packaging. Bioinicia has achieved materials with tailored polarity including super hydrophobic properties but also amphiphobic ones, a quite peculiar behavior that is much less reported in the literature. In the case of OPV surfaces, hydrophobicity will allow the panels to self-clean from dirty rain, whereas the same effect will allow facilitating the emptying and therefore reduce leftover at end of life in case of polar liquids/pastes being packaged (e.g. oil in water emulsions for cosmetics). The process required a novel multistep approach that has been patented by Bioinicia on how to use electro-hydrodynamic processes for obtaining stable layers with target characteristics.

Biography:

Sallahuddin Panhwar is a PhD Student of US-Pakistan Center for Advanced Studies in Water (USPCAS-W) at Mehran Univeristy of Enineering & Technology Jamshoro, Pakistan. Currently he is exchnage visiting scholar at the Univerosty of Utah, U.S.A. He has published more than 8 research papers in reputed journals and attended national and international conferences.

Abstract:

The aim of this study was to develop a simple electrochemical sensor for detection of (E.coli 25922) from water using gold nanoparticles. The water security and microbiological defense applications are globally concerns because of accuracy in the results and time saving technology. The traditional detection method of bacteria is requiring more time for the results. The biosensor reduce the detection time from 2 to 3 days to less than one hour with a simple identification method. The detection of pathogenic bacteria (E.coli 25922) is pivotal to public health for the water and food security. The electrochemical detection is applied for the detection of E. coli. However, in resulting the lowest bacterial concentration was weekly at 1 x 101 CFU/ml and the strongly on 1 x 106 CFU/ml. The electrochemical signal was increased with the increasing concentration of E. Cali. These results confirmed that the AuNPs-GCE is an effective approach to highly sensitive detection for the E.coli.