Akhilesh Dubey
Nitte University, India
Title: Design and comparative evaluation of targeted drug delivery of magnetic responsive polymeric micro particles of carboplatin.
Biography
Biography: Akhilesh Dubey
Abstract
The purpose of this study was to prepare and evaluate Carboplatin loaded polymeric magnetic microspheres for specific targeting. Methodology: It was prepared by emulsion-solvent evaporation method and evaluated with respect to particle size analysis, entrapment efficiency, IR studies, DSC, Swelling kinetics, magnetite content, in vitro magnetic responsiveness in a 0.21 kgauss magnetic field, in vitro drug release studies, in vivo drug targeting studies and stability studies. Results & Discussions: Spherical particles of average 169.3 nm to 285 nm in diameter and incorporation efficiency up to 77.91% were obtained. By chemical analysis, total percentage of Fe2O3 in the microspheres was found between 69 % - 96.68 %. Cumulative percent drug release after 8 hours were 99.31%, 98.89%, 99.47% for F-1 to F-3 MMS and after 24 hours 98.755 %, 98.33 %, 99.93 % was found for F-4-F-6 MMS respectively.
Conclusion: Results of in vitro magnetic responsiveness and in vivo targeting demonstrated that the retention of microspheres in presence of magnetic field was significantly more than those in the absence of the magnetic field. Stability studies showed that maximum drug content was found in the samples stored at 4°C. This study was a satisfactory preliminary attempt in development of magnetically modulated novel parenteral carrier for CPt. However magnetic field strength and gradient, distribution of the magnetite in the microspheres, application time of the magnetic field and in vitro in vivo co- relationship under diseased state are the most likely parameters which need to be optimized for the successful use of this delivery system in localized drug therapy.