Mahdieh Heydarigoojani
TU University of Vienna, Austria
Title: Preparation and characterization a biodegradable mPEG-PCL micelles as a controlled release formulation for Curcumin-Docetaxel for treatment of Atherosclerosis
Biography
Biography: Mahdieh Heydarigoojani
Abstract
In Atherosclerosis, vessels wall getting narrow and stiff. It is refers to buildup LDL(low density lipoprotein) and as a result, blood and nutrition can not pass through artery. Also Endothelial cells are injured and smooth muscle cells immigrate into the Intima. Therefore anticancer drugs would be appropriate choice for treatment. Curcumin and Docetaxel showed anti inflammatory and anti proliferative effects respectively. But their clinical application has been limited due to the fact that hydrophobicity and poor bioavailability. For this reason a potent mPEGPCL micelle system was synthesized and release profile of Curcumin and Docetaxel from drug- loaded micells was characterized.