Hippolyte Durand
University of Grenoble Alps,France
Title: The use of cellulose nanofibrils from wood as an innovative drug carrier in medical devices
Biography
Biography: Hippolyte Durand
Abstract
For several decades now, Cellulose Nanofibrils (CNF) from wood are of high interest in many research fields. They turned out to have high specific area, low density, excellent mechanical properties and chemical reactivity, besides their character of renewable resource. Highly entangled networks of such nanofibrils (5-20nm in width and 1-5µm long) are formed easily, resulting in films with high mechanical and barrier properties that make them interesting candidates for a number of applications, as seen recently in the medical field. The surface functionalization of these nanofibrils allows researchers to bring new properties to this wonderful material in order to incorporate it in new innovative bio-based products. The purpose of this work is to use CNF as a drug carrier in order to develop bioactive medical devices. CNF surface were first functionalized with drugs either by covalent or non-covalent binding and then incorporated in a matrix of collagen based material or used as films. Both types of samples, composites and films, are produced by solvent casting in controlled conditions. The drug release study of these medical device prototypes was conducted in-vitro in different model release medium such as PBS and enzyme containing solutions and gels. The use of CNF as drug carrier permitted to extend the duration of the drug release, resulting in an innovative and controlled drug delivery. This project intends to bring new bio-active products to the market of medical devices in order to ease post-surgery treatments and improve wound healing