3^rd International Conference and Exhibition on Pharmaceutical Nanotechnology and Nanomedicine September 22-23, 2021 London, UK

Nermin E. Eleraky from Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Vaginal administration of drugs suffers from many limitations, e.g., the short contact time of the drug with the mucosa or continuous carrier wash-out. Thus, the development of new carriers for gynecological use is necessary. Celecoxib, a selective cyclo-oxygenase-2 inhibitor, has been administered orally as an anti-inflammatory drug. It is a poorly water-soluble drug with oral bioavailability of around 40%. Besides, long-term oral administration of celecoxib produces gastrointestinal side effects. The hypothesis of the present work was to augment the permeation of celecoxib through the vaginal mucosa via its incorporation within chitosan-coated polymeric nanocapsules formulation.