4^th International Conference and Exhibition on Pharmaceutical Nanotechnology and Nanomedicine September 16-16, 2022 Vancouver, Canada

Biography:

Jiwan Jyoti has completed her M.sc at the age of 25 years from Punjab Agricultural University, Ludhiana. She has also done PGDCA and one semester course in interactive skills and personality enhancement from Punjab Agricultural University.  She is awarded ICAR award and best letter award (selective approach) published in Hindustan times newspaper. Her master’s research topic was “indigenous use of medicinal plants for digestive problems in Punjab”. She got International Richard Kuhn research award 2015 in enthnobilogy.  4 research papers and 2 abstracts have published in different journals and proceedings. Approximate 40 letters published in different newspapers. 4 articles and pamphlets also published. she have more than 5 years of experience as women extension officer  where She is also awarded towards Kaizen award and exemplary work in women empowerment award given by National Dairy Development Board, Anand, Gujarat on occasion of World Milk Day (1 June 2018). She has conducted various awareness programmes regarding medicinal plants, silage, clean milk production etc. She also attented National / International level workshops and conferences and got certificates. 

Abstract:

The study entitled “Indigenous use of medicinal plants for digestive problems in Punjab” was undertaken with the objectives to study the level of awareness and extent of use of medicinal plants by women for digestive problems and to determine the relationship of personal, socio-economic characteristics of the respondents with their level of awareness and extent of use of medicinal plants. The study was conducted in three socio-cultural regions i.e. Majha, Malwa, and Doaba of Punjab state.  A sample of 240 women heads was selected randomly from three districts- Gurdaspur from Majha, Faridkot from Malwa and Hoshairpur from Doaba.  The data was collected with the help of structured interview schedule. Results of the study revealed that majority of the respondents had medium level of awareness and low level of extent of use of medicinal plants. The reasons cited for the use of medicinal plants were that elders always used these, have no side effects, cost effective and easily available. The reasons stated for non-use were that allopathic medicines are easily available, time consuming preparation and quick relief with allopathic medicines. It was also found that education and family income had significant negative relationship with the level of awareness as well as extent of use of medicinal plants. Whereas age and social participation was positively related with awareness and use of medicinal plants.

Biography:

Dr. Pawandeep Kaur has completed her PhD at the age of 28 years (November, 2020) from Thapar Institute of Engineering and Technology, Patiala, Punjab, India. She have expertise in the preparation of receptor targeted protein protected nanomaterials and in vitro diabetic and non-diabetic wound healing. She have 5 first author publications in reputed journals and many other publications. She also published 2 book chapters.

Abstract:

Statement of the Problem: 422 million people, in 2016, have diabetes due to excess free body glucose in their body fluids which leads to various problems including retinopathy, neuropathy, arthritis, damage blood vessels and also causes a delay in wound healing. At the site of the wound, TNF-É‘, IFN-ϒ, IL-1β, and IL-6 pro-inflammatory cytokines causes generation of free radicals leading to inflammation which become persistent in diabetes. Insulin induces expression of IL-4/IL-13, IL-10 anti-inflammatory cytokines etc which further down regulates NFkβP65/P65 assembly. Insulin shifts the equilibrium towards NFkβP50/P65 and leads to down regulation of inflammatory cytokines like IL-6, IL-10 etc through STAT6, STAT3 and c-Maf activation causing inflammatory condition nullification. Insulin is a peptide hormone that plays multiple functions in our body, like control inflammation, increase in cell differentiation, lipid and protein biosynthesis, etc., and controlling glucose levels in the blood through glucose metabolism. The purpose of this study is to form the nanoformulations of insulin and use as a wound healing agent. Findings: The explored nanoformulations of insulin are biocompatible, stable, helps in cell division and migration, and wound healing. The IAgNP showed enhanced in vitro cell migration in both diabetic and no diabetic conditions compared to controls. In vivo histology evaluation showed a significant decrease in leukocyte infiltration, faster collagen deposition, and rapid re-epithelization anti-inflammatory activity, which is beneficial in treating chronic wounds. The in vivo studies showed a rapid decrease in inflammatory (IL-6 and TNF-α) cytokines and increased anti-inflammatory (IL-10) cytokines. IZnQCs and ICuQCs showed specific receptor binding, bioimaging, and wound healing properties. In IZnQCs, both insulin and zinc showed a synergistic effect through targeting IR and phosphorylating the same. Conclusion & Significance: These novel formulations are helpful in the wound recovery and wound monitoring wound and generate hope for better management of wounds, epically diabetic conditions.

Biography:

Dr. Thankaraj Salammal Sheena is currently a Postdoctoral researcher at the Bharthiyar cancer theranostics centre, Bharathiyar University, Tamil Nadu, INDIA. She received her Ph.D from the Centre for Nanoscience and Nanotechnology, Bharathidhasan University, INDIA. Her research interest is focused on the Raman spectroscopy, plasmonics, SERS, label free DNA detection, nanomedicine, bio and nanosystems to engineer surfaces for nanoscale biosensing, biospectroscopy.

Abstract:

Raman spectroscopy is widely used as an excellent analytical tool for molecular structure determination. With the advent of lasers for excitation, Raman measurements afford the valuable information for molecular characterization of complex molecular systems. Importantly, it’s very useful in measuring the dynamic response of the molecules such as biofluids, cells and tissues. This presentation will provide an overview of biomedical applications of Raman spectroscopy and imaging, highlighting the potentials as well as challenges and limitations. This will be further outlined the recent developments in disintegration of molecules in the cells after the drug exposure and the real-time, quantitative diagnostic information in vitro level will be discussed.

Biography:

Dr. Sumaira Anjum has her expertise in Synthesis and biomedical applications of Nanoparticles. She has synthesized a large variety of metallic and metal oxide nanoparticles and evaluate their activities for treatment of various diseases. She is has published many papers in International Journals regarding the Nanotechnology and Nanomedicines.

Abstract:

The trend of using biological entities particularly plant extracts for nanoparticles (NPs) synthesis has expedited in recent years due to environmental safety, cost effectiveness, simplicity and sustainability of green route. Moreover, the morphology of NPs could be fine-tuned by applying abiotic factors such as LEDs which enhance the bio-reduction of precursor salt and excites phytochemicals during the green synthesis. Given this, in present study the green synthesis of AgNPs was carried out using by Dalbergia sissoo leaves extract under the illumination of red, green, blue, yellow and white LEDs. Phytochemical analysis revealed that D. sissoo was enriched with phenolic (23.6 ± 0.76 mg GAE/g DW) as well as flavonoids content (1.65± 0.01 mg QE/g DW) which attributed to high FRSA (80.84 ± 0.87 %). The phytochemical profile reflected upon the effective synthesis of AgNPs as alcohols and phenols were mainly involved in capping and bio-reduction revealed from FTIR analysis. Moreover, XRD analysis showed face center cubic crystalline nature of AgNPs with interesting finding that LEDs helped in reducing the size of AgNPs significantly. Y-DS-AgNPs (34.63 nm) being smallest in size as compared to control (87.35 nm). LEDs not only reduced the size of AgNPs but SEM analysis showed synthesis of non-agglomerated differently shaped AgNPs including spherical, triangular, hexagonal as compared to mixed shape control AgNPs. Theses green biocompatible AgNPs showed extraordinary therapeutic potential specially B-DS-AgNPs resulted in highest anti-oxidant (FRAP 485.6 ± 9.6 µM TEAC; CUPRAC 588.1 ± 8.4 µM TEAC; ABTS 323.4 ± 10.4 µM and ORAC 469.2 ± 11.3 µM TEAC), anti-glycation (63.3 ± 2 % and 33.1 ± 3 % inhibition of vesperlysine-like AGEs and pentosidine-like AGEs) as well as anti-bacterial activities. While Y-DS-AgNPs effectively inhibited HepG2 cells growth (cell viability 26.01 ± 1.56 %) by inducing intracellular ROS/RNS generation (3807.62 ± 236.63 relative DHR-123 fluorescence), disrupting mitochondrial membrane potential (1839.29 ± 162.45 RFU) via caspase-3 gene activation (419.15 ± 106.51 log 2-fold change) and enhanced caspase-3/7 activity (137.26 ± 41.13 RFU/mg protein). Lastly, these NPs showed mild toxicity towards brine shrimp and caused moderate hRBCs hemolysis, showing their biosafe nature which can be enhanced at lower concentrations. Here we conclude that external factors such as LEDs are effective in controlling the morphology of AgNPs which reflects upon their enhanced biological efficacy.

Biography:

I am Surendra Adusumalli, I have done PhD in pharmacology from Kanpur University, India and a Master’s in international business from the University of Salford, Manchester UK. I have very good research in pharmacology and nanotechnological applications in drug discovery and design. I have more than 10 years of experience in pre-clinical, clinical pharmacology, molecular pharmacology, and clinical trials. I published my research data in many open-source research articles in the field of pharmaceutical sciences and I have many years of experience in teaching and administration both in hospital and education institutions. In recent days I am mainly focusing nanotechnology applications in various domains of life sciences and biomedical sciences

Abstract:

In recent years, researchers and medication designers have been paying a significant amount of attention to novel nanotechnology techniques to improve drug delivery to the central nervous system (CNS). The treatment of neurological conditions, including Alzheimer's disease, Parkinson's disease, brain tumours, and stroke, may be significantly impacted by nanotechnology in the not-too-distant future. Several studies have shown that nanomaterials have been effectively employed for the treatment of illnesses of the central nervous system (CNS), including neurodegeneration. In this context, nanocarriers have been essential in facilitating the targeted administration of chemotherapeutics, which has resulted in the effective prevention of disease development in malignant brain tumours. Therefore, the most effective use of nanomaterials is the use of these compounds in the treatment of CNS disorder, as this application improves the overall impact of the medicine and underlines the significance of nano-therapeutics. Treatments for CNS illnesses have advanced in recent decades, yet many patients have few alternatives. Nanotechnology is a promising new strategy to treat neurological disorders that might revolutionize CNS-targeted therapies. Nanoengineered molecules may traverse the blood–brain barrier, target particular cells or signaling systems, react to endogenous cues, or function as a matrix to enhance axon elongation and cell survival. The great diversity of available nanotechnologies permits the selection of a nanoscale material best matched to a CNS disorder's treatment problems. The purpose of this research was to review the evidence on the uses of nanotechnology in the creation of drug delivery systems that have the capability of passing through the blood-brain barrier (BBB) to transport therapeutic drugs to the central nervous system (CNS)

Biography:

Abstract:

Biography:

SIAVASH AZARBANI has completed his PHARM.D at the age of 25 years from AJUMS University School of Medicine.  He has published 1 papers in reputed journals .

Abstract:

Background and Objective: The side effects of NSAIDS drugs, have caused increasing interest of scientists in herbal medicines as alternative treatment. In this study, the effect of anti inflammatory of seed and fruit of date palm hydroalcolic extracts , due to having antioxidants, was studied.Materials and Methods: In this study, the extraxts of date palm seed and fruit were prepared by maceration method in 70% alcohol. Eighty male rats Wistar, divided into 10 groups of eight in each, 4 groups received different doses (100, 200, 400 and 600 mg/kg) of seed extract and 4 other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and the positive control aspirin (300mg/kg) and the negative control group saline (5ml/kg) via injection intraperitoneally. Half an hour later all animals received 100 µl of 1% carrageenan into the rats hind paw subcutaneous. The changes in rats paw edema was measured by plethysmometer every hour for five hours.Results: The effect of all of the doses of date palm seed extract on edema were less than aspirine (P<0.05). But there was no significant difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin group. The Dose 400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assignded as the best dose.Conclusion: It is likely that with further studies on different model of animals and also on human model the palm fruit extract could be used for pain treatment.

Biography:

Bereket Bahiru has his expertise in conducting evaluation of pharmaceutical supply chain practices in health facilities and expertise on providing supportive supervision for stakeholders how to improve the status of supply chain practices. He is actively involved on doing various researches related to pharmaceutical care including pharmaceutical supply chain management, rational drug use, pharmacoeconomics and pharmacotherapy. 

Abstract:

Background: Supply chain practices are various activities taken by the management of any organization for better workability of the whole supply chain and it is the backbone of the healthcare system because healthcare service is highly dependent on the availability medicines. Therefore, this study aimed to assess the status of supply chain practices and associated factors in public health facilities found in west Gojjam zone.Method and Materials: A descriptive cross-sectional study design supported with qualitative study was used. The data were collected with self-administered questionaries and in-depth face-to-face interviews from April/30 to June 30 2018. Epi-Data and SPSS version 20 was utilized for data entry and analysis, respectively. Simple and multiple linear regressions were done and A variable with a p-value less than 0.05 was considered as significantly associated. The qualitative data were analyzed with thematic analysis technique. Result: A total of 425 questionnaires were distributed to respondents and 413(97.2%) questionnaires were filled and returned successfully. Procurement, after-procurement service, and monitoring and evaluation were under-performed supply chain practices with a mean value of 2.85, 2.24, and 1.86, respectively. Conversely, the storage practice was a relatively better-performed supply chain practice with a mean value of 3.34. The multiple linear regression analyses also discovered that the number of trainings, the IPLS skill of the staff, management support, and the distance from PFSA were significantly associated with the most of the supply chain practices. Besides, limited medicine availability at PFSA, budget shortage, delayed reimbursement by health insurance agency, and absence of technicians who are capable of medical equipment maintenance services were identifies as the major challenges for supply chain practices.Conclusion: Generally, the status of implementation of the supply chain practices in public health facilities was drifted. Besides, there were many factors identified as constraints for effective operation of supply chain practices

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Biography:

Dr.V.O. Fadipe holds a PhD degree in Chemistry (Organic/Natural Product) from University of Zululand, South Africa. He hold MBA(Finance) from University of Lagos to add up his management skill.  He is presently Principal Research Fellow /Assistant Director, Federal Ministry of Science and Technology, Abuja, Nigeria. He has several research publications in chemistry of natural product for the treatment of TB. His research interest is in the bio-prospecting for drug lead candidates from natural products (plant and animal) for management & treatment TB and repositioning of existing drugs for infectious diseases. He is a member of several learned society in chemistry.

Abstract:

Tuberculosis (TB) is highly endemic disease world-wide. One of the commonly used first line drugs for anti-TB therapy (ATT) is isoniazid (INH). Isoniazid is known to be majorly metabolized and detoxified in liver by both phase I and phase II group of drug metabolizing enzymes. The drug and along with its metabolite are toxic and during its assimilation process cause injury to liver. The work presented here involves investigation of co-crystals involving isoniazid and oleanolic acid. A 1:1 co-crystal involving isoniazid, a foremost first-line drugs recommended by the World Health Organisation for the treatment of tuberculosis, which causes damage to the liver and Oleanolic acid, a hepatotoxicity naturally occurring compound, have been synthesized for the first time. Considering drug combination perspective, this is an interesting pharmaceutical co-crystal because of the known side effect of isoniazid therapy which might be improved upon by the presence of the oleanolic acid. The co-crystal compound was characterized using PXRD, TGA and SEM which were further evaluated for in vitro anti-TB and cytotoxicity index, using Human Embryonic Kidney (HEK 293) and Human Hepatocellular carcinoma (HepG2) cells. The PXRD of the synthesized co-crystal compound maintained crystalline nature like isoniazid for the three methods, TGA for all the three methods have cleavage values from 220^{0 C}- 360^{O C}, and the SEM images obtained from the three synthetic methods appears rod-like in nature. The co-crystal of OA with INH, increased the anti-TB MIC values for the three synthetic methods used as follows(a) Solvent evaporation(1.06µM) ;(b) Solvent drop (0.50µM) ;(c) Direct grinding (0.61 µM). The cytotoxicity test of the co-crystal system on the two-human cell lines (HEK 293 and HepG2) were found to be IC₅₀ ≥ 300ug/ml. The finding of the current work is that, co-crystal compound of OA with INH is probable and could be utilized to design better treatment for tuberculosis disease, which can further be extended to the treatment of HIV/TB co-infection.

Biography:

Prof. Mohammed Sani Haruna has two PhDs in Electrical Power Engineering and Entrepreneurship. He is presently the Executive Vice Chairman/Chief Executive Officer of National Agency for Science and Engineering Infrastructure (NASENI), Abuja, Nigeria. He has diverse practical working experiences which cut cross Industry, Academic and Government Institutions. In addition to his position as EVC/CEO of NASENI, he is currently a visiting Professor to Nigerian Turkish Nile University (NTNU), Abuja, Nigeria. He has strong research interest is in Materials Science & Engineering and Nanotechnology with several research publications.

Abstract:

Studies have shown that nanomaterials remain one of the most promising materials for modern and advance in the development of science and technology. In medicine particularly, cure and management of chronic diseases have been discovered through application of nanochemistry. Development of synthesis protocols for realising nanomaterials over a range of sizes, shapes, and chemical compositions and biological activity is therefore an important application of nanochemistry in medicine. The remarkable biological activity dependent physico-chemical properties of co-crystal systems involved which have been fascinated and inspired research activity in this direction.   In this presentation therefore, attention will be focused on the background information on the compounds involved, the synthetic methods to prepare a co-crystal system from the two solid organic compounds for better management and treatment of infectious diseases particularly tuberculosis, and its various characterization techniques will be discussed.

Biography:

Ramin Ataee is PharmD,PhD in pharmacoloy from Tehran Uninversity of Medical Sciences in 2009 as followings with H-index 11 ,They are some of his qualifications and short C.V1-Researcher of Institute Pasteur,Amol Branch 2000-2012Assistant Prof of Pharmacology MUMS 2012-no, 6 months scholarship  QIMR,Brisbane Australia 20092-three  months grant, trainee ship, Armand Frappier Institute,Montreal Canada,Editorial board of sciafrijournal ,Editorial board of International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS),Published Articles :60Articles in ISI or PubMed:30Research projects:30,PharmD or Bsc Thesis supervisor:30,Published books:3,Iranian Pharmacy council member,Iranian Medical council member-Australian Society of Medical research (ASMR) member ,Fields of researches:-Cancer Pharmacology-Neuro-Pharmacology-Herbal medicine researches and diabetes

Abstract:

Background: Curcumin is a natural polyphenolic material with antioxidative, anti-inflammatory, and anticancer effects. In this study, we attempted to assay anti proliferative and apoptotic properties of polymeric micelles of curcumin on two colorectal cancer cell lines and normal human fibroblast cells. Method: In this experimental study, cancer cells HT29, HCT116 and normal human fibroblast cells (HGF) were subjected to concentrations of Nano- curcumin (1, 50, 100, 250, and 500 µg/ml). After incubation for 48 hours, cell viability was assessed with "MTT"(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Annexin V-FITC and Propidium iodide staining were done with flow cytometry for evaluation of apoptosis. The results were shown as mean ± standard deviation. Statistical significance was assessed utilizing ANOVA and Dunnetts t-test (P < 0.01). Results: According to MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results, IC50 value of Nano- curcumin in HT29, HCT116, and HGF were 70.63, 123.9, and 168.53 µg/ml, respectively. We also discovered that Nano-curcumin can make indicative apoptosis in cancer cells, which could be compared with cisplatin<0.01. Conclusion: These  results revealed remarkable anti-proliferative and apoptotic effects of polymeric Nano-micelles of curcumin in colorectal cancer cell lines.

Biography:

Dr. Mohamed Abbas Ibrahim is a professor of Pharmaceutics, Al Azhar University, Assiut, Egypt. Currently, he is a professor in Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, King Saud University, Saudi Arabia. He earned a Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany, in collaboration with Al-Azhar University, Cairo, Egypt. His research interests include biomaterials as drug delivery systems, pelletization, nanotechnology and tablet technology and polymeric drug delivery systems. He supervised more than 10 master and Ph.D. students in Egypt and Saudi Arabia. Dr. He published more than 100 research and review articles, in addition to book chapters in these areas.

Abstract:

Nanotechnology became a widespread technology in recent years in several medical and pharmaceutical applications. The major goals in designing nanoparticles as a delivery system include enhancing bioavailability by enhancing solubility and dissolution rate, targeting the drug to specific organs and controlling drug release rate. Quality by design (QbD) encourages the pharmaceutical industry to use risk management and science-based manufacturing principles to gain process and product understanding and thus assures quality of the product. The lecture will discuss the application of QbD approach in the pharmaceutical nanotechnology.  Response surface methodology using computer based factorial design to study the effect of critical factors on various quality attributes of APG nanoparticles will be discussed. Based on the optimization procedures, risk assessment and using prior knowledge and experience will be focused to define the criticality of factors based on their impact by Ishikawa fishbone diagram and preliminary hazard analysis (PHA) tool.

Biography:

Rashid Mahmood has Master Degree in Analytical Chemistry and MS in Total Quality Management. He is having over 19 years of experience of Pharmaceutical Technical Operations and has represented his country as a keynote speaker in many international conferences.  He has presented various talks in USA, Canada, UK and UAE on Cleaning Validation, GXP, Quality Risk Management, Role of Mass Spectrometry in Pharmaceuticals and on new Drug Delivery Systems. Currently he is working as General Manager Technical Operations in Surge Laboratories Private Limited, Manufacturer of Microencapsulated APIs, Liquid & Sterile Dry Powder Parentrals. Surge Laboratories is one the best export oriented organization of Pakistan.

Abstract:

Nanotechnology commonly refers to structures that are up to several hundred nanometers in size. Nanomedicines and nano drug delivery systems are relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Novel drug delivery systems have several advantages over conventional multi dose therapy. Nanoparticles can offer significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in different route of administration and the capability to deliver both hydrophilic and hydrophobic drug molecules. A well-designed drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a particular drug. The intent of the study is to highlight the potential of nanoparticle formulation and their applications in delivery of drug molecules. This study will also describe the challenges and future nanotechnology strategies to overcome limitations in this field.

Biography:

Shanmukha Raju has his expertise in evaluation and passion in improving the health and wellbeing. His open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. He has built this model after 5 years of experience in research, evaluation and teaching. The research is based on Roadblocks to translational advances on metastasis research. Nano-particle technology is an encouraging strategy for treating breast cancer metastasis. This approach is responsive to all stakeholders and has a different way of focusing

Abstract:

Cancer metastasis is the primary cause of high mortality in breast cancer patients. In this study, we loaded an anti-cancer drug, docetaxel (DTX), into polymeric microspheres (DTX-loaded polymeric microspheres, PCMs), and explored their therapeutic efficacy in breast cancer metastasis. The characteristics of PCMs were investigated, and their anti-metastatic efficacy was assessed using in vitro and in vivo evaluations. PCMs had an average diameter of 50.13±11.96 nm with a DTX encapsulation efficiency of 97.02%±0.97%. PCMs could be effectively internalized into metastatic 4T1 breast cancer cells in vitro. DTX (10 ng/mL) or an equivalent concentration in PCMs did not significantly affected the viability of 4T1 cells, but dramatically decreased the cell migration activities. In an orthotopic metastatic breast cancer model, intravenously administered PCMs could be efficiently delivered to the tumor sites, resulting in a 71.6% inhibition of tumor growth and a 93.5% reduction of lung metastases. Taken together, our results verify the anti-metastatic efficacy of PCMs, thus providing an encouraging strategy for treating breast cancer metastasis.