Day :
- The Evolution of Nanomedicine with the Re-Evolution of Nanotechnology
Location: 3
Session Introduction
Kunal Joon
NIIMS, India
Title: how and why did the brain evolve? What are the molecular determinants of individual brain development? How lactic is are matured brain ?
Biography:
Worked on brain mapping in Science beam and assistant is Nishant Sharma
Abstract:
Brain theory
Development of brain starts from embryonic stage ASPM gene
Is responsible for the Development of the brain
Aim : observing different brain of the animals and comparison with human brain
Apparatus : dissected brain of human, amphibian,aves and reptiles
Procedure
Observe structures in the microscopes.
Observation : different stages of development of the brain was observed according to need .no convolution in aquatic to amphibians
Little convolution in reptiles to small mammals
Highly convoluted and specialised brain in human
Why and how did brain evolve
Brain evolved as a central functioning unit because as organisms
Start increasing in size and start developing new structure than
DNA modified accordingly and generated a new gene ASMP gene which created new cells neurons and these develop peripheral nervous system in hydra and small organism and according to complexity neurons gathered and developed the CNS and after that complexity increased the brain was developed in the fishes .
DNA forward rolling occurred in the small organisms to humans
According to need , complexity and environment and internal environment of cell brain evolved
What are molecular determinant of individual brain ?
Molecular determinants of brain are basically amount of neurotransmitters secreted and amount of hormones secreted from the glands present in the brain .
The neurotransmitters and secretions of neurohormones vary According to needs and conditions of organisms
Even presence electrical transmission is also considered as the molecular determinant of brain as their count varies from person to person and even organisms to organisms
How plastic is matured brain ?
Depends on the memory and convolution of brain
Brain is divided into two parts
Subconscious and conscious
Subconscious constitute more than 70% of our brain and stores photogenic and learned memory
Generates thought and dreams
Conscious works on thought and dreams constitute less than 30%of brain.
So subconscious brain is more plastic than Conscious brain as we can generate the thought.
So accordingly the plasticity of brain depends on the convolution of brain and moldiness of brain .
- Nanomedicine and Nanobiotechnology
Location: 4
Session Introduction
Zahid Hasan
NCBA&E Main Campus Lahore, Pakistan
Title: Nano medicine: A Novel Model based Coulomb Explosion for the Study of Nano-particles of Gold in the Treatment of Breast Cancer
Biography:
Mr. Zahid Hasan is a Ph.D scholar belongs to Lahore Pakistan. He is assistant professor in well reputed charter university (NCBA&E) in main campus of Lahore Pakistan. His area of research is Nano robotic applications for diagnosis of chronic diseases and treatment. In 2019 he has physically attended Nanotech conference in Paris France and achieved good performance award. He interested to use Nano technologies applications in life science by using numerical methods. Recently he is working on blood cancer research with the combine efforts of Ontologies, machine learning nanotechnology and emerging technology of Internet of medical things (IOMT) and cloud computing approaches. He has expertise in innovative evaluation and passion in improving the medical challenges and wellbeing of humanity. He has developed novel model that aim to improve healthcare by taking into account the perspectives and need of all stakeholders. The proposed model appears to be particularly responsive to the context in which it is being applied, as it takes into account the specific circumstances and needs of the healthcare system being evaluated. This could potentially make it more effective in improving healthcare outcomes compared to more traditional evaluation approaches.
Abstract:
Nanotechnologist and medical researchers are still involved in a fighting against a high number of serious and complex diseases like breast cancer. Breast cancer remains a significant global medical issue among all ages of women and need to serious attention in this direction for research, investment, and effective and safely treatment. Traditional treatments including surgery, radiation therapy, chemotherapy, targeted therapy, and hormone therapy are not have effective results and have many limitations.
In this research work, coulomb explosion model is proposed to design “Heat control system” that will work as heat therapy for the treatment of the fatal cancer cells at molecular and Nano atomic level on the bases of “See and Treat” using Nano heat sensors and Nano Cameras. For controlling the intensity of heat we used the magical properties of coated Gold Nano- Particles with less than 100nm in our proposed research work. The gold nanoparticles are irradiated with a laser beam to initiate Coulomb explosion. The resulting explosion generates a high-energy shockwaves, which causes damage to the cancer cells and leads to their destruction by controlling the intensity of heat to induce hyperthermia, which involves heating the cancerous tissue to a temperature between 41-45°C to selectively kill the cancer cells. The heat control system has several advantages over traditional cancer treatments such as chemotherapy or radiation therapy. Firstly, hyperthermia can selectively target cancer cells, leaving healthy tissue unharmed. Secondly, it can be combined with other cancer treatments to enhance their effectiveness. Finally, it is a non-invasive procedure that is well-tolerated by patients.
Moreover we used the finite element method to simulate the temperature distribution in the breast tissue during the treatment. This proposed model will be evaluated on the Thermo Phoresis Nt. The numerical results obtained in graphical form and show how Nano-particles of Gold preserve their energy as well as how they can be used in the treatment of cancer cells. The results are obtained by using MATLAB simulation.
- Nanoparticles As Precise Drug Delivery Systems
Location: 9
Session Introduction
Kianoush Gholami
University of Mashhad, Iran.
Title: The function of chitosan as the effective nano carrier for antibacterial and anticancer diseases
Biography:
Kianoush Gholami, He is an undergraduate student at Ferdowsi University of Mashhad, Iran, and he has a major in Cell and Molecular Biology. Aspired science researcher with more than one year of experience working in the field of Cellular Biology, Nanotechnology, Drug Delivery, and Cancer Therapy. He is interested in microbiological investigations. Research assistant and hands-on experience with molecular techniques, researching scientific literature and writing technical reports. Experienced administrative and planning, with high levels of the team playing.
Abstract:
Cancer is taken into account as one of the most prominent life-threatening diseases worldwide, with increasing incidence and mortality rates in the last decades. Reportedly, the number of new cancer cases per year is expected to rise up to 24 million until 2035. Beside unhealthy life style, specific bacterial infections including Helicobacter pylori, Salmonella Enteritidis, Salmonella Typhi and Chlamydia trachomatis could induce neoplastic changes in gastric, colon, gallbladder, cervical and ovarian cells, respectively. Use of anticancer agents is a routine modality, which could be applied alone or in combination with surgery and radiotherapy. However, severe side effects, poor solubility and nonspecific dissemination of chemical drugs are major challenges in cancer treatment that need to be overcome.