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Muhammad Shahid Khan

Muhammad Shahid Khan

NovaMed Pharmaceuticals (Pvt) Ltd., Pakistan

Title: Formulation development and in-vitro characterization of orodispersible tablets of Piroxicam and Lidocaine HCl for use in dental pain

Biography

Biography: Muhammad Shahid Khan

Abstract

The purpose of this research study was formulation development and in-vitro characterization of orodispersible tablets of Piroxicam and Lidocaine HCl along with the development and validation of the novel method of simultaneous estimation of both the drugs on HPLC. The aim was to develop a product that will provide immediate relief from the pain of dental origin, due to the local action of lidocaine in the mouth and also produce long-lasting analgesia by piroxicam after absorption. Orodispersible tablets of Piroxicam and Lidocaine HCl were developed by direct compression method. FTIR spectroscopy was used to study drug-drug and drugs-excipients compatibility. The FTIR spectra showed that there was no interaction between the two drugs and also between the drugs and excipients which proved that all the ingredients are compatible. The assay method for simultaneous estimation of both the drugs on HPLC was developed successfully. The developed method was also validated by following ICH guidelines.