Pharmaceutical Nanotechnology and Nanomedicine

Emerging Nanomedicine

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Currently, the treatment of HIV requires regular oral dosing of HIV drugs, and chronic oral dosing has significant complications that arise from the high pill burden experienced by many patients across populations with varying conditions leading to non-adherence to therapies. Recent evaluation of HIV patient groups have shown a willingness to switch to nanomedicine alternatives if benefits can be shown. Research efforts by the Liverpool team have focused on the development of new oral therapies, using Solid Drug Nanoparticle (SDN) technology which can improve drug absorption into the body, reducing both the dose and the cost per dose and enabling existing healthcare budgets to treat more patients.In a four-year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, the new nanoparticle not only killed tumour cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill. "Previous monotherapies have not extended the lifetimes of mice bearing this type of tumour".